This laboratory is focusing on the identification and characterisation of genes associated with schizophrenia and substance dependence.
There are projects on the identification of DNA variants in the dysbindin gene that are directly involved in the development of schizophrenia; the follow-up of a candidate gene for schizophrenia, PIPKIIa which is located in a schizophrenia-linked region on chromosome 10p.
Projects underway include:
- An international collaborative large-scale genotyping of families with schizophrenia which is nearing completion.
- Combined and comparative analysis of genotyping data obtained for the dysbindin gene is underway in a group of German and Irish families.
- Molecular genetic investigation of schizophrenia in multiple affected families from Indonesia is also underway.
- There is a local collaboration which will address identification of genetic factors which are important for the development of heroin addiction.
- Unravelling the suggested genetic background for co-morbidity of Parkinson’s disease with depression and other psychiatric disorders using association studies with a candidate gene.